If you have a reaction from an injection, be sure to talk to your doctor about it. Redness, itching, pain, or swelling are common reactions, and can usually be avoided by changing the method of injection. Some people have a reaction at the injection site. Self-injection is administered with prefilled syringes or auto-injectors - injection pens or e-devices - that come with the appropriate dose of medication. Many injectable biologics are now available for self-injection and can be safely taken at home. A subcutaneous injection uses a needle to release medication into the fatty tissue under the skin. Injections of biologics can be quickly administered with a syringe in a clinical setting, similar to other types of shots or vaccines. It works well, and I have no side effects from it.” Injections: What To Expect “I just had my monthly Orencia infusion today. “I was resistant and scared of infusions at first, but was in enough misery to give it a try after going through so many drugs that worked, then stopped or had negative side effects,” one myRAteam member wrote. It is not uncommon for people with RA to be wary of infusions, but many people adjust well to the procedure. Some biologic drug infusions take as little as 15 minutes, while others may take several hours.Īn infusion is a relatively painless procedure, usually experienced only as a pinprick when the needle is inserted into a vein. An infusion pump may be used to regulate the dosage of the biologic. The needle will deliver the medication from a tube attached to a bag that slowly releases the drug in drip over an allotted time to provide the necessary dosage. To get an infusion, you will go to a medical facility and have an IV needle inserted into your hand or arm. For me, it took about two months to really kick in!” said one myRAteam member. Some people with RA may experience quick relief when starting a biologic drug, but many biologics take time to start working, regardless of whether the drug is taken by infusion or injection. Injected biologics are administered with a needle that releases the medication under the skin. An infusion uses a needle to administer a biologic drug directly into a vein for release into the blood system. Infusions and injections are different ways of delivering a biologic medication. The Difference Between Infusion and Injection Read more about the different types of biologics for RA. The selective costimulation modulator Orencia (abatacept) is available for both subcutaneous injection and infusion. Some interleukin inhibitors are also available for infusion. Interleukin (IL) inhibitors, such as Actemra (tocilizumab) and Kineret (anakinra), are available for subcutaneous injection. B-Cell Inhibitorsī-cell inhibitors, such as Rituxan (rituximab), are only available for infusion. Other TNF inhibitors, such as Remicade (infliximab), may be available by infusion. Tumor necrosis factor-alpha inhibitors (TNF inhibitors), such as Cimzia (certolizumab pegol), Enbrel (etanercept), and Humira (adalimumab), are only available for subcutaneous injection. There are four classes of biologic drugs that are available in various forms. Guide: How to find the right treatment for your RA condition These drugs will require IV infusions to be properly administered at the right dosage, usually in a clinical setting. In addition, some biologic therapies require high doses that may not be appropriate for injection. Compounds for biologic medications consist of large molecules that cannot be adequately absorbed in the digestive system if taken orally, which is why these medications must be taken by IV infusion or by injection.Ĭompound sensitivity, risk of degradation, and viscosity - or thickness of the fluid - are some of the factors that determine which biologic drugs must be infused, rather than injected. They are made with genetically modified proteins designed to target specific areas of the immune system that overreact and cause inflammation, joint pain, and joint damage in people with RA. Biologics are highly complex and sensitive compounds.
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QIWI, being a multiplatform solution, makes it possible to pay for any services through QIWI terminals and the Internet. Through QIWI, customers can buy tickets, pay for e-shops purchases and much more. QIWI is a convenient service for day-to-day payments, from mobile communications to communal facilities and bank loans. In 2008 OSMP launched its retail brand QIWI. In the future, subsidiaries will be opened in Turkmenia, Kirgizia and some non ex-USSR countries. In foreign countries, OSMP works through its subsidiaries which are created for payment system market development and payments technologies promotion in Ukraine, Georgia, Kazakhstan, Tajikistan, Uzbekistan, Belarus, Moldova, Armenia and China. Skype, associated trademarks and logos and the “S” symbol are trademarks of Skype Limited.įounded in 2004, OSPM is now electronic payments market leader, as well as the leading supplier of complex technology solutions for payment receiving points in Russia and abroad. Skype is not a replacement for your traditional telephone service and cannot be used for emergency calling. Skype is an eBay company ( NASDAQ: EBAY).Īccess to a broadband Internet connection is required. Download Skype to your computer or mobile phone at Everyday, people everywhere also use Skype to make low-cost calls to landlines and mobiles. Millions of individuals and businesses use Skype to make free video and voice calls, send instant messages and share files with other Skype users. Skype is software that enables the world’s conversations. The ability for users to use the QIWI Private Cabinet system is a result of the payment system developed by Skype and Yandex.Money, Skype’s long-standing partner in Russia, who has been providing online payment services to Skype users in Russia since December 2006. “I am sure that QIWI customers will see the value of this new opportunity and will actively use it”. “Launch of sales of Skype voucher codes through QIWI cash-in kiosks makes the paid features of this very popular software available to its users across Russia”, said Andrey Popkov, Executive Director of QIWI Private Cabinet project. To meet the demand for Skype’s paid features it is a natural step for Skype to take advantage of the ubiquity of cash-in kiosks and their popularity in Russia”. “whether it’s ease-of-use, being able to use Skype on your mobile phone when on the move, or making payment options simple. “Skype constantly seeks new opportunities to become more accessible and trouble-free for our users,” said Enrico Noseda, Skype’s Director for European Market Development. This offers an alternative and easy way to purchase Skype Credit for users who do not have a bank card, and a great way to buy credit for their friends and family too. Users then redeem their voucher code at to instantly top-up their Skype account. They can now be purchased from Russia’s biggest cash-in QIWI kiosk chain, in a way that for millions of Russians has become customary to pay for mobile, ISP, cable TV and home utility bills. QIWI Private Cabinet payment system is the first to offer the Skype voucher codes for sale in Russia. Skype Credit can also be used to purchase other paid features such as Skype’s subscriptions or to send SMS’s to mobiles. While Skype-to-Skype voice and video calls and instant messaging are free on Skype, users need a little Skype Credit on their account if they want to save money and use Skype to call their friends, family and colleagues on their phones or mobiles. In response to demand for a convenient payment option in Russia, this makes Skype’s paid-for features more accessible to Russian Skype users by providing a familiar and convenient way to buy Skype Credit. MOSCOW - Skype today announced that Skype Credit voucher codes are now available to buy from 72.000 QIWI cash-in kiosks across Russia. Store the cookies in an airtight container for up to 5 days.To make sure you have some melted chocolate on the top of the cookies, lightly press extra chocolate chips / chocolate chunks in to the top of the cookies before they go in to the oven.Make sure your oven is preheated to the temperature required.Use a spoon or spatula for mixing in the eggs and dry ingredients. Only use the mixer for whisking the butter, sugar and vanilla together. Don’t over mix the dough – this will make the cookies tough.Measuring flour using kitchen scales is the most accurate way of weighing the flour.I prefer to chop a block of chocolate for chocolate chunks rather than chocolate chips. Use good quality chocolate for the best chocolate flavour.Add a pinch of salt and use vanilla for the maximum flavour.Make sure your butter is softened before you begin to make these cookies.I would recommend you use a stand mixer to cream the butter and sugar rather than a hand mixer. Cool on the tray for 5 minutes before transferring to wire rack to cool completely.Place in the preheated oven and bake until golden brown.Gently fold in the chocolate chips/ chopped chocolate.Stir in the flour, baking soda and salt with a spoon until just combine.Add the beaten egg and stir in by hand.Using electric beaters or a stand mixer, beat the softened butter and white sugar with vanilla until light and fluffy.Baking soda – this makes the cookies less cakey, and gives those crispy melt in the mouth edges.Dark chocolate, semi sweet chocolate, milk chocolate or white chocolate are all delicious in these cookies. Chocolate chips – or roughly chopped chocolate.This adds a lovely rich, bakery style taste to your cookie and extra depth of flavour. Vanilla – vanilla bean paste, or vanilla extract.Butter – I like to use unsalted butter and then add a pinch of salt in to the dough, but you can use salted butter and leave out the salt if you prefer.They keep in an airtight tin for a week, and can be frozen.You will not notice there is no brown sugar in these cookies.This easy recipe takes just minutes to prepare and you do not need to rest the dough in the fridge – meaning you can have soft chocolate chip cookies in 20 minutes!.Brown sugar adds colour and a soft moistness to cookie, but what happens when you have no brown sugar? Well, you can still bake a batch of choc chip cookies! This recipe for chocolate chip cookies without brown sugar shows you can bake soft chocolate chip cookies with white sugar! Why We Love This Recipe Chocolate Chip Cookies without Brown SugarĬan you make chocolate chip cookies with no brown sugar?Ĭhocolate chip cookies, that classic cookie flavour loved by millions, are often made with brown sugar.Can you make chocolate chip cookies with no brown sugar?.This recipe was originally published June 2015.Soft and chewy with tender crispy edges, these easy chocolate chip cookies without brown sugar are so good you will be making cookies with white sugar from now on! So simple to make, and ready in under 20 minutes, these homemade cookies will soon become a family favourite. (To be completely honest, I add chocolate chips sometimes too.) Other cookie recipes to make today I get this question all the time, and the answer is- yes of course! If you can’t bear to leave out the chocolate, or if you want to turn this into your go-to chocolate chip cookie recipe, feel free to add 1-2 cups of whatever kind of chocolate chips or chunks you like. Just when I thought there was nothing new to do with chocolate chip cookies! You have to give these a try, I promise you’ll fall in love too. Add coarse see salt to warm baked cookies, if desired.Portion onto cookie sheet and bake for 9-11 minutes.This will take a few minutes mixing by hand, but it will com together to make a thick cookie scoop. Add the flour, baking soda, and salt and stir until combined.This will lighten the color and texture even more. Wait for a few minutes, then mix again for 30 more seconds.You’ll notice the mixture lightens in color and starts to thicken. Add eggs and egg yolk one at a time, mixing for about 30 seconds after each addition.The mixture will be very soft and greasy. Mix melted browned butter with sugar, brown sugar, and vanilla until combined.I borrowed this cookie recipe from Cook’s Illustrated and I love how easy it is. Not only does it start melted butter, but it also is mixed completely by hand. This cookie recipe is a little different from other chocolate chip cookie recipes. More Baking Tips » Also, no mixer required! Copper has never been clinically proven to provide any benefit for pain, inflammation, or antimicrobial paths. This can lead to discomfort during longer wear times as well as rubbing against skin causing blisters and other damage!Ĭopper Fit Compression Socks have many downsides, mostly in the gimmicky nature of copper-infused socks. There are many benefits to the NextGen Active Compression Socks over their counterparts when deciding which compression socks are best for you but here are some of our favorites.īombas Compression Socks have been designed specifically for the average-sized American foot, leaving larger feet feeling squeezed in tight spaces. They also come with multiple sizing options so it’s easy to find one that will provide optimum comfort and support while wearing them all day long. NextGen Active Compression Socks come in a wide range of sizes and widths, meaning that no matter your size or shape there is likely to be a sock that fits just right. The Fit Factor: NextGen Active Compression Socks Copper Fit also comes with multiple sizing options so it’s easy to find one that will provide optimum comfort and support while wearing them all day long. The fit factor of both Copper Fit Compression Socks and Bombas Compression Socks is a major consideration when deciding which compression socks are the best for you.īombas Compression Socks come in a wide range of sizes and widths, meaning that no matter your size or shape there is likely to be a sock that fits just right. The cool thing about NextGen Active Compression Socks is they come in different colors! So not only are you getting socks that can be worn casually or as activewear, but ones that look great - even when standing out from your favorite pair of shoes! The Fit Factor: Copper Fit Compression Socks vs Bombas Compression Socks They’re designed with an arch compression system that reduces strain on the Achilles tendon for improved performance while also reducing fatigue in the calf area. NextGen Active Compression Socks are made of a blend of polyester and elastane to provide all-day support, protection and comfort. What’s more? They’re available for men and women of all sizes. The company claims their style is unisex so it can be worn by both men and women.Ĭopper Fit Compression Socks have been clinically proven to help alleviate some symptoms associated with varicose veins such as heaviness in legs, pain or soreness when walking up stairs, tiredness after standing too long on feet, occasional cramps in calf muscles while at rest (especially at night), difficulty sleeping because leg feels heavy or stiff when lying down flat on back. Copper Fit socks are made from a blend of copper fibers and compression nylon to provide the perfect amount of support for those with venous insufficiency. If you want to know more about these products or how they compare against one another then keep reading! Copper Fit Compression SocksĬopper Fit Compression Socks are made from natural, breathable materials that will improve circulation and reduce swelling. This article will compare these three brands in terms of price, quality, comfort level and other important factors before giving our final verdict on which brand is better. Copper Fit Compression Socks vs Bombas Compression Socks vs NextGen Active Compression Socks 2021 To find out which brand is best for you based on their features/benefits go back or scroll down to continue reading our blog post content. Since then, this technique has become widely used by athletes of all varieties for recovery and injury prevention purposes!! In the 1930s, a scientist created compression socks as an experiment to help with circulation and blood flow in his patients’ legs. Compression technology has been around since the 1930s but only recently have businesses realized its necessity as an activewear staple! The history behind compression socks is interesting. To help with this decision-making process, we have created a list of three brands that produce excellent compression socks: Copper Fit, Bombas, and NextGen Active. Are you looking for the best compression socks? There are plenty of options to choose from, but it can be difficult to find out which ones work best. In Jotun, you play Thora, a Viking warrior who died an inglorious death and must prove herself to the Gods to enter Valhalla.Įxplore vast regions of Norse Purgatory to find runes to unleash the jotun, giant Norse elementals. Dopo una settimana poco ricca di interesse da parte della community per via dellultimo regalo, Epic Games Store offre gratuitamente a partire da oggi tre ottimi giochi per PC. Jotun is a hand-drawn action-exploration game set in Norse mythology. Explore vast regions of Norse Purgatory to find runes to unleash the jotun, giant Norse elementals. Epic Games has announced that Jotun: Valhalla Edition is now available for free on Epic Games Store. Blueprint Genetics’ Plus Analysis is a combination of both sequencing and deletion/duplication (copy number variant (CNV)) analysis. Plus analysis increases the likelihood of finding a genetic diagnosis for your patient, as large deletions and duplications cannot be detected using sequence analysis alone. The diagnostic yield varies depending on the assay used, referring healthcare professional, hospital and country. These sample types were selected in order to maximize the likelihood for high-quality DNA yield. Please see our sequencing and detection performance table for details regarding our ability to detect different types of alterations (Table).Īssays have been validated for various sample types including EDTA-blood, isolated DNA (excluding from formalin fixed paraffin embedded tissue), saliva and dry blood spots (filter cards). Our panels are sectioned from our high-quality, clinical grade NGS assay. The genes on the panel have been carefully selected based on scientific literature, mutation databases and our experience. The sensitivity of this test may be reduced if DNA is extracted by a laboratory other than Blueprint Genetics.įor additional information, please refer to the Test performance section.
Neon tetras and ember tetras are both omnivorous, opportunistic feeders that are unfussy in their diet and will enjoy a wide range of fish foods.īecause they’re so small, flake foods are the obvious choice, rather than pellets, which can get lodged in the throats and choke small fish. Set your aquarium heater’s thermostat to between 73☏-78☏ to keep both species happy. Since tannins are present in their natural environment, some aquarists believe they are beneficial for the health of these South American fish.Īs for water temperature requirements, neon tetras are a little bit fussier than ember tetras and don’t enjoy water temperatures exceeding 78☏. If your water is hard or alkaline, you could try softening it by adding materials that contain tannins such as driftwood, peat, and Indian almond leaves. Both require soft, acidic water with a pH of less than 7, and a GDH of 5-12 will satisfy both species. These two species have very similar needs when it comes to water parameters. Neon Tetra and Ember Tetra Water Parameters While you need to make sure your water parameters, filtration, and tank environment are set up correctly, these fish are relatively forgiving and tolerate a range of conditions. Neon Tetra and Ember Tetra Level of Careīoth neon tetra and ember tetra are great fish for beginners. On the whole, neon tetras are a peaceful community tank species, too. Neon tetra can occasionally be feisty with other fish, but usually only during breeding time, or when stressed. Ember tetras are as close as you’ll get to the model community tank fish, and will hardly ever show aggression toward other species unless they’re very stressed (see notes on fin nipping later). Neon Tetra and Ember Tetra TemperamentĮmber tetra and neon tetra are both relatively peaceful fish. That’s one reason that neon tetras are such great tank mates for them! Growing to only 1.5 inches in captivity, neon tetras are only slightly larger, and will seldom pose any threat to the tiny ember tetra. Usually growing to an adult size of less than an inch, these tiny fish are great for small aquariums, but only when kept with other small fish. But what makes them good tank mates for each other? Neon Tetra and Ember Tetra SizeĮmber tetras are one of the smallest tropical fish on the market. Neon tetra and ember tetra are in the same genus, meaning they’re very closely related to one another. Keeping Neon Tetra and Ember Tetra Together Their tiny size and peaceful nature make them a good choice for beginners looking to set up their first tropical community tank. Their deep orange-red colors look stunning when set against a lush green planted aquarium. Since their discovery, they’ve become more and more popular and are now one of the most sought-after tetra species. Ember tetras are a fairly recent introduction to the aquarium trade – they weren’t even discovered in the wild until 1987! These fish come from the Araguaia River Basin in Brazil – not so far away from their neon cousins. There is no need for third-party software. Simply double-clicking the file opens it. MP4 files open in the operating system's default video player. Many consider MP4 to be one of the best video formats available today. It is also a popular video format for streaming over the Internet, such as on YouTube. It is compatible with a wide range of devices and operating systems, using a codec to compress file size, resulting in a file that is easy to manage and store. MPEG-4 (MP4) is a container video format that can store multimedia data, usually audio and video. They are Masterpoint green points data, which is obsolete and TeslaCrypt 3.0 ransomware encrypted file, which is malware that demanded ransom in bitcoins, but is thankfully now deactivated and no longer a threat.ĭeveloped by: ISO/ IEC, Moving Pictures Experts Group Keep in mind that two other file types use the MP3 extension. Users can also preview MP3 files.Īnother program that can open MP3 files is VLC media player. Simply clicking on the file will open it in iTunes or Windows Media Player, depending on your preferred platform. Due to small size and acceptable quality, MP3 files are accessible to a wide audience, as well as easy to store and share.īecause MP3 files are so prevalent, most major audio playback programs support them. MP3 files are the most widely-used audio file for consumers. MPEG-1 Audio Layer III or MPEG-2 Audio Layer III (MP3) is a digital, audio-coding format used to compress a sound sequence into a very small file to enable digital storage and transmission. The first official Memorial Day was observed on May 30, 1868. “We have all lost a giant and, for many of us, a deep and close friendship.“The willingness of America’s veterans to sacrifice for our country has earned them our lasting gratitude.” – Jeff Miller “It was a moment in history that lifted the heart of a nation and boosted morale in a world that was still at a low ebb after the war. “His achievement transcended sport, let alone athletics,” added Coe. Bannister’s assault allowed mankind to enter a world filled with new possibilities. It was as much of a psychological barrier as it was a physical barrier. “The world’s best runners had been attempting the four-minute barrier for a quarter of a century. “One year after the coronation of a young Queen Elizabeth II and after man conquered Everest, Roger Bannister ran the first sub-four-minute mile with the help of his friends Chris Chataway and Chris Brasher. “On the, Roger made the impossible possible,” said Coe, speaking at the launch event of IAAF Heritage. IAAF President Sebastian Coe, who had hugely been inspired by Bannister in his own career, paid tribute to the former world record-holder. "It's in the nature of things, there's a gentle irony to it." "I have seen, and looked after, patients with so many neurological and other disorders that I am not surprised I have acquired an illness," he said at the time. He continued to run to keep fit until he broke his ankle in a car accident in 1975, the same year he was knighted.īannister was diagnosed with neurological disorder Parkinson’s disease in 2011. The pair met later in the year at the British Empire Games and, in a race billed as the ‘miracle mile’, Bannister won in a British record of 3:58.8, just short of Landy’s world record of 3:57.9.Īt the end of 1954, having also won the European 1500m title, Bannister retired from athletics to pursue his medical studies full-time and later became a consultant neurologist. His world record lasted 45 days until it was broken by Landy. The time was three."Īnd that told the crowd all they needed to know their roar drowned out the rest of the announcement. "Ladies and gentlemen, here is the result of event nine, the one mile: first, number 41, RG Bannister, Amateur Athletic Association and formerly of Exeter and Merton Colleges, Oxford, with a time which is a new meeting and track record, and which - subject to ratification - will be a new English native, British national, all-comers, European, British Empire and world record. Stadium announcer Norris McWhirter, who went on to co-publish and co-edit the Guinness Book of Records, excited the crowd by delaying the announcement of Bannister’s time. The pace slipped slightly on the third lap as the bell sounded in 3:01, but Bannister chased Chataway for a further half lap before kicking into the lead and charging for the line. Paced through the first lap in 58 seconds and half way in 1:58, Bannister was on target for his goal. Bannister, who was a medical student at the time, had started his day with a shift at a hospital in London before heading over to Oxford for the 6pm race. īritish teammates Chris Brasher and Chris Chataway assisted with the pace-making duties. But several other leading runners of that generation - including USA’s Wes Santee and Australia’s John Landy - were also pursuing the same goal.īannister seized his opportunity during a meeting between the British AAA and Oxford University at the Iffley Road track on. A medical student at the time, Bannister used his medical knowledge to devise his own training regime and investigate the mechanical aspects of running.Ī British record of 4:03.6 in May 1953 made him realise that his target was a realistic ambition. His biggest achievement, however, came two years later.Īfter the 1952 Olympics, he set himself the goal of becoming the first man to run a sub-four-minute mile. Bannister fulfilled that goal and went on to finish fourth in the 1500m in Helsinki, setting a British record of 3:46.40. Instead, he channelled his focus into training for the 1952 Olympics. Following a year of light training, he ran a 4:24.6 mile at the age of 18 and was considered for the British Olympic team in 1948, but he declined selection. The IAAF is deeply saddened to hear that Roger Bannister, the first man to run a mile within four minutes, died on Saturday (3) at the age of 88.īorn in Harrow in 1929, Bannister was inspired to take up athletics after watching Sydney Wooderson in the 1940s. |
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